OUR GUARANTEE TO YOU: ABSOLUTELY THE MOST UNEXPECTED STORY YOU'LL READ ALL YEAR! Something has gone terribly wrong on Earth, and it's spreading from human to human - quickly, unstoppably. The Baxter Building is not immune - and before they can even realize there is a problem, everyone on the Fantastic Four is compromised! ...Everyone, that is, save for Jo and Nicki - the young adopted children of Ben and Alicia, whose alien Kree and Skrull physiology leaves them immune. But what can two children do to save an entire world all by themselves? And what if what's needed for a cure is physically impossible? Jo and Nicki take center stage in this mind-bending single-issue epic! PLUS: A SPECIAL BACKUP STORY CELEBRATING DISABILITY PRIDE MONTH!