NUEVA YORK – UNDER SYMBIOTE SEIGE! Miguel O'Hara, the SPIDER-MAN of 2099, is more powerful – and more violent – than ever before after bonding to a symbiote, and his battle with VENOM 2099 threatens to push him over the brink! The heroes (and villains) of 2099 rally to try to save Nueva York... and save Miguel from himself. But it may already be too late!